
Buses from Des Moines, IA to Osceola, MO travel the 295mi (474.76km) journey, taking approximately 10h, 54m. Usually, there is 1 bus operating per day. While the average ticket price for this journey is around $120, you can find the cheapest bus tickets for as low as $120.
Osceola, MO 64776
All aboard for adventure in Des Moines, IA—a hidden gem in the heart of the Midwest that's sure to surprise and delight. Stepping off your bus to Des Moines, you'll find a town bustling with charm and brimming with activities. Start your exploration at the striking Pappajohn Sculpture Park, where art meets open air. Hungry? The lively East Village offers diverse dining that won't disappoint.
History buffs will enjoy a trip to the State Capitol, a masterpiece of 19th-century architecture with a golden dome that proudly shines over the city. Ready for some fun? Head to Adventureland Park, where thrilling rides await, or unwind in the serene beauty of the Greater Des Moines Botanical Garden.
Des Moines is also famous for its vibrant arts scene, with the Des Moines Art Center leading the charge. And don't forget the Saturday morning Downtown Farmers' Market, splendid any day of the week. Whether it’s art, architecture, or amusement parks, Des Moines serves up a hearty slice of Midwestern hospitality.






Osceola, MO, has the heart of the Midwest and a welcoming spirit that makes every visit feel like coming home. With its quaint charm, Osceola invites you to explore its picturesque surroundings and unique local character. Take in the vistas at Truman Lake, where fishing and boating are a way of life. History enthusiasts will find themselves drawn to the Civil War history that weaves through the town, offering a glimpse into the past.
The local flavor isn't limited to scenery—savor renowned Osceola Cheese, a must-try that embodies the town’s delightful hospitality. Wander through the delightful main street shops or take a moment to relax in one of the serene parks scattered across the area.
Osceola's cozy aura makes it a perfect destination for those seeking both relaxation and discovery. Ready to experience it all? Hop on a bus to Osceola, MO, and let the town's friendly embrace and scenic charm create your travel memories.
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