View Current Travel Advisories
Trailways Home Page

Trailways Bus Tickets
from Knoxville, TN to Fort Myers, FL

(*) indicates a required field
Start typing the origin city to open location options, and then use the arrow keys to navigate to the origin city you want, then press enter to select that origin city
Start typing the destination city to open location options, and then use the arrow keys to navigate to the destination city you want, then press enter to select that destination city

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.

Bus Station Information for Fort Myers, FL

Fort Myers

Curbside Stop, use arrow keys or tab to explore more about this bus station

Fort Myers, FL 33901

Curbside Stop
Address
2250 Widman Way 
Fort Myers, FL 33901
Phone Number
(800) 858-8555
More Detailsabout Fort Myers Curbside Stop

Fort Myers (Edison Mall)

Curbside Stop, use arrow keys or tab to explore more about this bus station

Fort Myers, FL 33901

Curbside Stop
Address
4125 Cleveland Ave 
Fort Myers, FL 33901
Phone Number
(858) 800-8898
More Detailsabout Fort Myers (Edison Mall) Curbside Stop

Fort Myers (McDonalds - Daniels Parkway)

Curbside Stop, use arrow keys or tab to explore more about this bus station

Fort Myers, FL 33912

Curbside Stop
Address
13600 Indian Paint Ln 
Fort Myers, FL 33912
Phone Number
(858) 800-8898
More Detailsabout Fort Myers (McDonalds - Daniels Parkway) Curbside Stop

City InformationforKnoxville, TN

Roll into Knoxville, TN on a fresh set of wheels and you're in for a symphony of Southern charm and unique attractions. Nestled in the breathtaking Tennessee River Valley, this vibrant town weaves the spirit of the Smoky Mountains with its own eclectic mix of history, culture, and entertainment. Travel back in time with a visit to the historic Market Square, where street performers and local artists add a splash of color to your day. Feel the buzz at the Knoxville Museum of Art or catch a live performance at the Tennessee Theatre, where the melodies linger long after the curtains close.

Nature enthusiasts will delight in the Urban Wilderness, offering miles of trails that wind through lush landscapes just minutes from the city center. And hey, if you’re a college sports fan, catch a Tennessee Volunteers game and join the sea of orange at Neyland Stadium. Hop on a bus to Knoxville and immerse yourself in a town where every corner tells a story worth uncovering. Whether you're exploring solo or with a crew, Knoxville's welcoming warmth and dynamic spirit make it a road trip worth taking.

Scenic photo of {{ name }}
Scenic photo of {{ name }}
Scenic photo of {{ name }}

City InformationforFort Myers, FL

Nestled on the sunny Gulf Coast, Fort Myers, FL, charms visitors with its laid-back vibe and a seamless blend of nature and history. Hop off your bus to Fort Myers and dive into an array of activities waiting just for you. For beach lovers, the soft, sandy shores and vibrant marine life of Fort Myers Beach make it a dream destination. History enthusiasts will appreciate a peek into the past at the Edison and Ford Winter Estates, where you can explore inventive legacies nestled in lush gardens.

The town’s heart beats with local flair, wander around River District, with its mix of art galleries, eclectic shops, and lively dining spots. Nature lovers won’t want to miss the chance to kayak through Four Mile Cove Ecological Preserve, bringing you up close with Southwest Florida's unique mangrove ecosystem.

Whether you're unwinding on the beach or paddling through pristine waters, Fort Myers offers a delightful getaway. So go ahead, snag those bus tickets and discover this coastal gem for yourself!

Frequently Asked Questions about the Bus Ride

Discover our Most Popular Routes Nationwide