View Current Travel Advisories
Skip to Main Content
Trailways Home Page

Trailways Bus Tickets
from Lake City, FL to Myrtle Beach, SC

Choose one way or round trip:
(*) indicates a required field
Start typing the origin city to open location options, and then use the arrow keys to navigate to the origin city you want, then press enter to select that origin city
Start typing the destination city to open location options, and then use the arrow keys to navigate to the destination city you want, then press enter to select that destination city
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.

Bus Station Information for Myrtle Beach, SC

Myrtle Beach

Bus Station, use arrow keys or tab to explore more about this bus station

Myrtle Beach, SC 29577

Bus Station
Address
511 7th Avenue N 
Myrtle Beach, SC 29577
Phone Number
(800) 858-8555
More Detailsabout Myrtle Beach Bus Station

City InformationforLake City, FL

Grab your backpack and hop on a bus to Lake City, FL, a hidden gem that promises a blend of relaxation and adventure. This charming town, dotted with scenic lakes and rich history, is a perfect escape from the daily grind. Start your day exploring the Ichetucknee Springs State Park where crystal-clear springs invite you to dive right in or float leisurely on a tube.

For those intrigued by history, the Lake City Columbia County Historical Museum showcases fascinating artifacts in a picturesque 1870s-era house. And if you’re more of a thrill seeker, don’t miss the Osceola National Forest with its endless trails primed for hiking or biking amidst lush pine canopies.

If food is your love language, a stroll downtown will lead you to cozy, family-run diners serving up Southern comfort food that’ll fill both your heart and soul. Lake City’s friendly vibe invites you to unwind and explore, all while keeping your wallet happy. Book your bus to Lake City, FL today, and get ready for a charming slice of Floridian life!

City InformationforMyrtle Beach, SC

Let Myrtle Beach, SC, add a splash of adventure to your itinerary without splashing out! Whether you're a beach bum or a thrill-seeker, this coastal gem has got something for everyone. Start your day with a sunrise stroll along its sprawling sandy shores, perfect for finding those elusive, picture-perfect seashells. For thrill enthusiasts, Broadway at the Beach offers a fun-filled day of shopping, dining, and entertainment with attractions like Ripley’s Aquarium and live shows. Nature lovers can head to Myrtle Beach State Park for a relaxing hike or a picnic amid stunning ocean views. Meanwhile, golf lovers won't want to miss one of the area’s famed mini-golf courses.

Feeling hungry? Local seafood shacks serve up fresh, delectable catch-of-the-day specials that turn every meal into a coastal feast. And for those looking to experience history, the Hopsewee Plantation offers a glimpse into the past.

Planning your trip? Book a bus to Myrtle Beach and soak up all the sun-soaked memories this vibrant town has to offer. Adventure waits beyond every sand dune!

Frequently Asked Questions about the Bus Ride