View Current Travel Advisories

Trailways Bus Tickets
from Santa Ana, CA to Knoxville, TN

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Santa Ana, CA to Knoxville, TN

Buses from Santa Ana, CA to Knoxville, TN travel the 1923mi (3094.76km) journey, taking approximately 2d, 10h, 45m. Usually, there are 4 buses operating per day. While the average ticket price for this journey is around $485.46, you can find the cheapest bus tickets for as low as $445.95.

  • Distance
    1923mi (3094.76km)
  • Average trip duration
  • Average bus ticket price
    $485.46
  • Trips per day
    4
  • Top Carriers
    Greyhound Lines

Bus Station Information for Knoxville, TN

Knoxville

Curbside Stop, use arrow keys or tab to explore more about this bus station

Knoxville, TN 37914

Curbside Stop
Address
100 Kirkwood St 
Knoxville, TN 37914
Phone Number
(800) 858-8555
More Detailsabout Knoxville Curbside Stop

City InformationforSanta Ana, CA

Pack your bags and jump on a bus to Santa Ana, CA, where a unique blend of culture and creativity awaits. This vibrant town, nestled in Southern California, is your gateway to excitement, with a local vibe you won't find anywhere else. Swing by the Bowers Museum to soak in fascinating global exhibits or explore the heart of the town at the Santa Ana Zoo, where exotic animals entertain visitors of all ages.

For your theatrical skip, the Yost Theater offers unforgettable live performances in a historic setting. Feeling hungry? Saunter through the 4th Street Market, where artisanal stalls serve up delicious bites that reflect the town's diverse culinary offerings. The scene doesn’t end there – street art and galleries add a splash of color throughout the city.

Santa Ana's energetic streets and cultural gems make it the perfect getaway. Whether you’re a history buff, an art lover, or just craving something tasty, getting on that "bus to Santa Ana" ensures you’re front and center for experiences that won’t disappoint.

City InformationforKnoxville, TN

Roll into Knoxville, TN on a fresh set of wheels and you're in for a symphony of Southern charm and unique attractions. Nestled in the breathtaking Tennessee River Valley, this vibrant town weaves the spirit of the Smoky Mountains with its own eclectic mix of history, culture, and entertainment. Travel back in time with a visit to the historic Market Square, where street performers and local artists add a splash of color to your day. Feel the buzz at the Knoxville Museum of Art or catch a live performance at the Tennessee Theatre, where the melodies linger long after the curtains close.

Nature enthusiasts will delight in the Urban Wilderness, offering miles of trails that wind through lush landscapes just minutes from the city center. And hey, if you’re a college sports fan, catch a Tennessee Volunteers game and join the sea of orange at Neyland Stadium. Hop on a bus to Knoxville and immerse yourself in a town where every corner tells a story worth uncovering. Whether you're exploring solo or with a crew, Knoxville's welcoming warmth and dynamic spirit make it a road trip worth taking.

Frequently Asked Questions about the Bus Ride

Make it easy to get from Santa Ana to Knoxville by taking a bus. Trailways offers 4 buses departing from Santa Ana to Knoxville every day. Schedule your bus trip to Knoxville today!