View Current Travel Advisories

Trailways Bus Tickets
from Iowa City, IA to Cape Girardeau, MO

Choose one way or round trip:
(*) indicates a required field
Type the date in date format 2 digit month slash 2 digit day slash 4 digit year or press tab to use the date picker pop up calendar

Travel made simple with Trailways

Unbeatable Prices

One of the best inventories of bus tickets in one place - with exclusive fares you won't find elsewhere.

Proven Reliability

On-time travel services - trust our reputation for reliable bus transportation.

Comfort and Convenience

Numerous upgraded buses with large leather recliners, free wi-fi, and power outlets for each seat.
Overview

About buses from Iowa City, IA to Cape Girardeau, MO

Buses from Iowa City, IA to Cape Girardeau, MO travel the 318mi (511.77km) journey, taking approximately 19h, 15m. Usually, there is 1 bus operating per day. While the average ticket price for this journey is around $107.96, you can find the cheapest bus tickets for as low as $107.96.

  • Distance
    318mi (511.77km)
  • Average trip duration
  • Average bus ticket price
    $107.96
  • Trips per day
    1
  • Top Carriers
    Greyhound Lines

Bus Station Information for Cape Girardeau, MO

Cape Girardeau

Curbside Stop, use arrow keys or tab to explore more about this bus station

Cape Girardeau, MO 63701

Curbside Stop
Address
49 Leming Ln 
Cape Girardeau, MO 63701
Phone Number
(800) 858-8555
More Detailsabout Cape Girardeau Curbside Stop

City InformationforIowa City, IA

Ready to explore one of the Midwest's hidden gems? Hop on a bus to Iowa City, IA, where a unique blend of culture, creativity, and charm awaits. Known for its vibrant literary heritage as a UNESCO City of Literature, you'll find yourself enveloped in a community that loves words almost as much as it loves a good cup of coffee.

Start your adventure at the famed Prairie Lights Bookstore, an independent treasure trove for bibliophiles. Take a stroll through the Downtown District, where local art and indie boutiques add a creative flair to your journey. If history’s your thing, the Old Capitol Museum on the University of Iowa campus offers a peek into the past with its stunning golden dome.

Feeling hungry? There's no shortage of eateries serving everything from farm-to-table delights to globally inspired dishes. The city’s culinary scene is as diverse as it is delicious. Whether you're on a quest for creativity or cool eateries, Iowa City has a little something for everyone. Get ready to discover your new favorite getaway!

Scenic photo of Iowa City, IAScenic photo of Iowa City, IAScenic photo of Iowa City, IA
Scenic photo of Iowa City, IA
Scenic photo of Iowa City, IA
Scenic photo of Iowa City, IA

Frequently Asked Questions about the Bus Ride

Make it easy to get from Iowa City to Cape Girardeau by taking a bus. Trailways has 1 Cape Girardeau-Iowa City trips starting at $107.96. Get your bus ticket to Cape Girardeau now!